Охрана природы в Израиле

In such country as Israel with its high industrialization and urbanization rates the environment protection is of key importance for preserving the biodiversity of nature. Awareness of the need to protect precious natural resources and landscapes of Israel forced to pass numerous laws on protection of nature and wild animals. These laws provide legal basis for protection of environment, natural resources, wild animals, unique nature features and places being of scientific and educational value in this country.Israel locates at the juncture of three continents combining different climatic and botanical regions which have led to appearance of the unique, by diversity and composition, plant and animal world. In Israel you can find 2800 plant varieties (of which 150 are endemics), 8 species of amphibia, 80 species of reptiles, 450 species of birds and 70 species of mammals. For protection of natural biodiversity there were established 224 nature preserves and 203 and historical heritage deserves special mention.In the recent years the governmental and public organizations have focused on development of the programs on environment management for monitoring and ensuring the required quality of water and air and for processing and utilization of solid wastes.Quite spectacular achievements are observed in reintroduction of predatory and bible species, protection of sea turtles, impoundment of the Hula valley and preservation of migratory birds. The government’s initiatives were welcomed by the public that joined in national parks which cover around 23% of the territory of Israel. The nature preserves and national parks represent the whole range of the natural heritage of Israel: Mediterranean forests, coastal and water landscapes, sand dunes, desert and crater landscapes and oases, while the unique archeological these activities. The environmental education, awareness and activities of the society have increased enormously which is proved by the growing number of nongovernmental environmental organizations — from a few in the 1990s to over one hundred nowadays. The greater attention is paid to collection and publication of environmental data.В такой стране, как Израиль, с высокими темпами индустриализации и урбанизации, охрана природы играет важную роль в обеспечении биоразнообразия природной среды. Признание необходимости защиты драгоценных природных и ландшафтных ресурсов Израиля привело к принятию многочисленных законов об охране природы и диких животных. Эти законы обеспечивают юридическое обоснование деятельности по защите окружающей среды, природных ресурсов, диких животных, уникальных уголков природы и мест, представляющих научный и образовательный интерес в Израиле.Географическое положение Израиля на стыке трех континентов, а также соединение различных климатических и ботанических регионов, привели к возникновению уникального по своему обилию и составу растительного и животного мира. Богатство биологического разнообразия Израиля выражается в 2800 видах растений (150 из которых эндемики Израиля), 8 видах земноводных, 80 видах рептилий, 450 видов птиц и 70 видов млекопитающих. Для охраны биоразнообразия природной среды на территории Израиля образовано 224 природных заповедников и 203 национальных парков. В результате около 23% территории Израиля являются охраняемыми природными заповедниками и национальными парками. Вместе заповедники и парки представляют весь спектр природного наследия Израиля — средиземноморские леса, прибрежные и водные ландшафты, песчаные дюны, пустынные и кратерные пейзажи и оазисы — а также его уникальное археологическое и историческое наследие.В последние годы правительственные и общественные организации сосредоточили внимание на разработке программ управления окружающей средой для мониторинга и обеспечения необходимого качества воды, воздуха, переработки и утилизации твердых отходов. Впечатляющие достижения были сделаны в таких областях, как реинтродукция хищных и библейских видов, защита морских черепах, подтопление долины Хула и сохранение перелетных птиц. Инициативы правительства сопровождались растущим участием общественности. Экологическое образование, осведомленность и активность общественности значительно возросли, о чем свидетельствует резкий рост числа неправительственных экологических организаций — от единиц в начале 90-х годов до более ста в настоящее время. Уделяется больше внимания сбору и публикации экологических данных

Parity-Violating Hydrodynamics in 2+1 Dimensions

We study relativistic hydrodynamics of normal fluids in two spatial dimensions. When the microscopic theory breaks parity, extra transport coefficients appear in the hydrodynamic regime, including the Hall viscosity, and the anomalous Hall conductivity. In this work we classify all the transport coefficients in first order hydrodynamics. We then use properties of response functions and the positivity of entropy production to restrict the possible coefficients in the constitutive relations. All the parity-breaking transport coefficients are dissipationless, and some of them are related to the thermodynamic response to an external magnetic field and to vorticity. In addition, we give a holographic example of a strongly interacting relativistic fluid where the parity-violating transport coefficients are computable.Comment: 39+1 page

A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site

We recently identified 68 genomic loci where common sequence variants are associated with platelet count and volume. Platelets are formed in the bone marrow by megakaryocytes, which are derived from hematopoietic stem cells by a process mainly controlled by transcription factors. The homeobox transcription factor MEIS1 is uniquely transcribed in megakaryocytes and not in the other lineage-committed blood cells. By ChIP-seq, we show that 5 of the 68 loci pinpoint a MEIS1 binding event within a group of 252 MK-overexpressed genes. In one such locus in DNM3, regulating platelet volume, the MEIS1 binding site falls within a region acting as an alternative promoter that is solely used in megakaryocytes, where allelic variation dictates different levels of a shorter transcript. The importance of dynamin activity to the latter stages of thrombopoiesis was confirmed by the observation that the inhibitor Dynasore reduced murine proplatelet for-mation in vitro

The neural processing of taste

Although there have been many recent advances in the field of gustatory neurobiology, our knowledge of how the nervous system is organized to process information about taste is still far from complete. Many studies on this topic have focused on understanding how gustatory neural circuits are spatially organized to represent information about taste quality (e.g., "sweet", "salty", "bitter", etc.). Arguments pertaining to this issue have largely centered on whether taste is carried by dedicated neural channels or a pattern of activity across a neural population. But there is now mounting evidence that the timing of neural events may also importantly contribute to the representation of taste. In this review, we attempt to summarize recent findings in the field that pertain to these issues. Both space and time are variables likely related to the mechanism of the gustatory neural code: information about taste appears to reside in spatial and temporal patterns of activation in gustatory neurons. What is more, the organization of the taste network in the brain would suggest that the parameters of space and time extend to the neural processing of gustatory information on a much grander scale

A Late Role for bmp2b in the Morphogenesis of Semicircular Canal Ducts in the Zebrafish Inner Ear

BACKGROUND:The Bone Morphogenetic Protein (BMP) genes bmp2 and bmp4 are expressed in highly conserved patterns in the developing vertebrate inner ear. It has, however, proved difficult to elucidate the function of BMPs during ear development as mutations in these genes cause early embryonic lethality. Previous studies using conditional approaches in mouse and chicken have shown that Bmp4 has a role in semicircular canal and crista development, but there is currently no direct evidence for the role of Bmp2 in the developing inner ear. METHODOLOGY/PRINCIPAL FINDINGS:We have used an RNA rescue strategy to test the role of bmp2b in the zebrafish inner ear directly. Injection of bmp2b or smad5 mRNA into homozygous mutant swirl (bmp2b(-/-)) embryos rescues the early patterning defects in these mutants and the fish survive to adulthood. As injected RNA will only last, at most, for the first few days of embryogenesis, all later development occurs in the absence of bmp2b function. Although rescued swirl adult fish are viable, they have balance defects suggestive of vestibular dysfunction. Analysis of the inner ears of these fish reveals a total absence of semicircular canal ducts, structures involved in the detection of angular motion. All other regions of the ear, including the ampullae and cristae, are present and appear normal. Early stages of otic development in rescued swirl embryos are also normal. CONCLUSIONS/SIGNIFICANCE:Our findings demonstrate a critical late role for bmp2b in the morphogenesis of semicircular canals in the zebrafish inner ear. This is the first demonstration of a developmental role for any gene during post-embryonic stages of otic morphogenesis in the zebrafish. Despite differences in the early stages of semicircular canal formation between zebrafish and amniotes, the role of Bmp2 in semicircular canal duct outgrowth is likely to be conserved between different vertebrate species

Advanced results of Fortelyzin® use in the FRIDOM1 study and real clinical practice

Aim. To study the effectiveness of Fortelyzin® in subgroups with different body weights in patients with ST-segment elevation acute myocardial infarction (STEMI) in the FRIDOM1 study and real clinical practice.Material and methods. Fortelyzin® was administered in a single-bolus dose of 15 mg over 10 seconds, regardless of the body weight of patients. Metalyse® was administered in a single-bolus dose of 30-50 mg over 10 seconds, depending on body weight. The one-year results of the FRIDOM1 study were evaluated by the clinical centers using telephone contact. Monitoring of Fortelyzin® use was carried out by inpatient physicians, emergency doctors and paramedics by filling out a monitoring sheet in the period from June 2013 to December 2021 in 19243 patients with STEMI.Results. In the FRIDOM1 study, the distribution of patients depending on body weight in the Fortelyzin® (n=190) and Metalyse® (n=191) drug groups was as follows: up to 60 kg — 4 people each (p=1,00); from 60 to 70 kg — 21 and 23 (p=0,87); from 70 to 80 kg — 39 and 43 (p=0,71), from 80 to 90 kg — 63 and 47 (p=0,07); from 90 to 100 kg — 30 and 41 (p=0,19); over 100 kg — 33 people (p=1,00) in each group. The effectiveness of thrombolysis according to electrocardiographic (ECG) data in the Fortelyzin® and Metalyse® groups was as follows: up to 60 kg — 75% each (p=1,00); from 60 to 70 kg — 76% vs 83% (p=0,72); from 70 to 80 kg — 82% vs 86% (p=0,76); from 80 to 90 kg — 81% vs 77% (p=0,64); from 90 to 100 kg — 80% vs 81% (p=1,00); over 100 kg — 79% vs 76% (p=1,00); in total — 80% vs 80% (p=0,87). The effectiveness of thrombolysis according to coronary angiography (CAG) (TIMI 2-3) in the Fortelyzin® and Metalyse® groups was as follows: up to 60 kg — 100% vs 50% (p=0,43); from 60 to 70 kg — 81% vs 67% (p=0,48); from 70 to 80 kg — 74% vs 84% (p=0,41); from 80 to 90 kg — 70% vs 72% (p=1,00); from 90 to 100 kg — 67% vs 66% (p=1,00); over 100 kg — 58% vs 64% (p=0,80); in total — 70% vs 71% (p=0,76). The one-year survival rate in the FRIDOM1 study in the Fortelyzin® and Metalyse® groups was 94% (p=0,91). The administration of Fortelyzin® in patients with STEMI caused blood flow restoration according to ECG data in 14624 of 19243 patients (76%), while according to CAG (TIMI 2-3) — in 3422 of 4805 patients (71%). Inhospital mortality was 5% (n=962), while intracranial hemorrhage developed in 0,5% (n=92).Conclusion. The use of Fortelyzin® in the FRIDOM1 study and in real clinical practice in a single-bolus (10 sec) dose of 15 mg in patients with STEMI with any body weight showed its high efficacy and safety, including at the prehospital stage

Acoustic Overexposure Increases the Expression of VGLUT-2 Mediated Projections from the Lateral Vestibular Nucleus to the Dorsal Cochlear Nucleus

The dorsal cochlear nucleus (DCN) is a first relay of the central auditory system as well as a site for integration of multimodal information. Vesicular glutamate transporters VGLUT-1 and VGLUT-2 selectively package glutamate into synaptic vesicles and are found to have different patterns of organization in the DCN. Whereas auditory nerve fibers predominantly co-label with VGLUT-1, somatosensory inputs predominantly co-label with VGLUT-2. Here, we used retrograde and anterograde transport of fluorescent conjugated dextran amine (DA) to demonstrate that the lateral vestibular nucleus (LVN) exhibits ipsilateral projections to both fusiform and deep layers of the rat DCN. Stimulating the LVN induced glutamatergic synaptic currents in fusiform cells and granule cell interneurones. We combined the dextran amine neuronal tracing method with immunohistochemistry and showed that labeled projections from the LVN are co-labeled with VGLUT-2 by contrast to VGLUT-1. Wistar rats were exposed to a loud single tone (15 kHz, 110 dB SPL) for 6 hours. Five days after acoustic overexposure, the level of expression of VGLUT-1 in the DCN was decreased whereas the level of expression of VGLUT-2 in the DCN was increased including terminals originating from the LVN. VGLUT-2 mediated projections from the LVN to the DCN are likely to play a role in the head position in response to sound. Amplification of VGLUT-2 expression after acoustic overexposure could be a compensatory mechanism from vestibular inputs in response to hearing loss and to a decrease of VGLUT-1 expression from auditory nerve fibers

Environment Protection in Israel

In such country as Israel with its high industrialization and urbanization rates the environment protection is of key importance for preserving the biodiversity of nature. Awareness of the need to protect precious natural resources and landscapes of Israel forced to pass numerous laws on protection of nature and wild animals. These laws provide legal basis for protection of environment, natural resources, wild animals, unique nature features and places being of scientific and educational value in this country.Israel locates at the juncture of three continents combining different climatic and botanical regions which have led to appearance of the unique, by diversity and composition, plant and animal world. In Israel you can find 2800 plant varieties (of which 150 are endemics), 8 species of amphibia, 80 species of reptiles, 450 species of birds and 70 species of mammals. For protection of natural biodiversity there were established 224 nature preserves and 203 and historical heritage deserves special mention.In the recent years the governmental and public organizations have focused on development of the programs on environment management for monitoring and ensuring the required quality of water and air and for processing and utilization of solid wastes.Quite spectacular achievements are observed in reintroduction of predatory and bible species, protection of sea turtles, impoundment of the Hula valley and preservation of migratory birds. The government’s initiatives were welcomed by the public that joined in national parks which cover around 23% of the territory of Israel. The nature preserves and national parks represent the whole range of the natural heritage of Israel: Mediterranean forests, coastal and water landscapes, sand dunes, desert and crater landscapes and oases, while the unique archeological these activities. The environmental education, awareness and activities of the society have increased enormously which is proved by the growing number of nongovernmental environmental organizations — from a few in the 1990s to over one hundred nowadays. The greater attention is paid to collection and publication of environmental data